Study of Naltrexone effects continues

Researchers at Standford are now into their next stage of clinical trials of looking at low doses of Naltrexone for use with fibromyalgia patients. The first study which was implemented early in 2007 showed hope that Naltrexone might work for fibro patients with little side effects. Typically, Naltrexone is used in 50 mg dose to help treat alcohol and opiate addiction. They tested the drug for fibro in a very low dose, around to 4.5 mg. Instead of blocking the bodies pain receptors, the dosage of the medication “modulated activity of glial cells to act as a neuroprotectant and suppressant of proinflammatory cytokines”. (medpagetoday) The study was lead by Jarred Younger, PhD and Sean Mackey, MD, PhD. Here’s a great chart showing their results:
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“Overall, self-reported, daily fibromyalgia symptoms (scale 0 – 100, with 100 being most severe symptoms). Time periods are: baseline, placebo, LDN, and washout. The data are separated into drug responders (solid line, 6 people) and drug nonresponders (broken line, 4 people). Drug responders are individuals who had at least a 30% greater reduction of symptoms during LDN versus placebo.” -stanford.edu

Hopefully by the end of this year we will know if the dug will help those of us with fibromyalgia.

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Link to Stanford post

ResearchChannel – An Update on Fibromyalgia

Here’s a great lecture from The Standford University Medical Center Health Hour:
ResearchChannel – An Update on Fibromyalgia

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